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Tivantinib

Catalog No.: 16070802
Cas No.: 905854-02-6
Purity : 98% by HPLC 
16070802 - Tivantinib | CAS 905854-02-6

Catalog number : 16070802

CAS number : 905854-02-6

分子式 : C23H19N3O2 

分子量 : 369.41 

Iupac 化学名称 : (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 

Smile : C1(=CN2CCCC3=CC=CC1=C23)[C@@H]2C(NC([C@H]2C2=CNC3=CC=CC=C23)=O)=O

InChiKey : UCEQXRCJXIVODC-PMACEKPBSA-N

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同义词ARQ197 Tivantinib 
英文同义词ARQ197 Tivantinib 
分子式C23H19N3O2 
分子量369.41 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC1(=CN2CCCC3=CC=CC1=C23)[C@@H]2C(NC([C@H]2C2=CNC3=CC=CC=C23)=O)=O
InChiKeyUCEQXRCJXIVODC-PMACEKPBSA-N
InChiInChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1
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Tivantinib (ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. 

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