Talabostat, also known as PT-100, is dipeptidyl peptidase inhibitor with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines.
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化学信息
| 名称 | Talabostat mesylate |
| Iupac 化学名称 | (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid methanesulfonic acid (1:1) |
| 同义词 | PT-100; PT100; PT 100; D05989; Val-boro-pro |
| 英文同义词 | PT-100; PT100; PT 100; D05989; Val-boro-pro |
| 分子式 | C10H23BN2O6S |
| 分子量 | 310.17 |
| Smile | B([C@@H]1CCCN1C(=O)[C@H](C(C)C)N)(O)O.CS(=O)(=O)O |
| InChiKey | OXYYOEIGQRXGPI-WSZWBAFRSA-N |
| InChi | InChI=1S/C9H19BN2O3.CH4O3S/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15;1-5(2,3)4/h6-8,14-15H,3-5,11H2,1-2H3;1H3,(H,2,3,4)/t7-,8-;/m0./s1 |
| Cas号 | 150080-09-4 |
| MDL | MFCD13194906 |
| 相关CAS号 | |
| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
| 海关编码 | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |