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THZ2

Catalog No.: 192252
Cas No.: 1604810-84-5
Purity : >98%

THZ2,是THZ1的类似物,具有治疗三阴性乳腺癌(TNBC)的潜力,是一种有效的选择性CDK7抑制剂,克服了THZ1在体内的不稳定性。IC50: CDK7= 13.9 nM;TNBC细胞= 10nM。

For research use only. We do not sell to patients.

Chemical Information

名称THZ2
Iupac 化学名称N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide
同义词THZ2; THZ 2; THZ-2.
英文同义词THZ2; THZ 2; THZ-2.
分子式C31H28ClN7O2
分子量566.06
SmileO=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN(C)C)=O)=C5
InChiKeyFONRCZUZCHXWBD-VGOFMYFVSA-N
InChiInChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6-11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+
Cas号1604810-84-5
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Ordering Information

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Formulation类白色至白色固体
纯度>98%
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO
Handling
运输条件可在常温下运输
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

192252 - THZ2 | CAS 1604810-84-5

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