TDZD-8
编号: 161009029
Cas号: 327036-89-5
纯度: 98% by HPLC
TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | TDZD-8 |
|---|---|
| Iupac 化学名称 | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
| 同义词 | TDZD8; TDZD-8; TDZD 8. GSK3 Inhibitor I; NP 01139. |
| 英文同义词 | TDZD8; TDZD-8; TDZD 8. GSK3 Inhibitor I; NP 01139. |
| 分子式 | C10H10N2O2S |
| 分子量 | 222.26 |
| Smile | C(C1=CC=CC=C1)N1C(N(SC1=O)C)=O |
| InChiKey | JDSJDASOXWCHPN-UHFFFAOYSA-N |
| InChi | InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3 |
| Cas号 | 327036-89-5 |
| 相关CAS号 |
订购信息
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