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TDZD-8

Catalog No.: 161009029
Cas No.: 327036-89-5
Purity : 98% by HPLC 
161009029 - TDZD-8 | CAS 327036-89-5

Catalog number : 161009029

CAS number : 327036-89-5

分子式 : C10H10N2O2S 

分子量 : 222.26 

Iupac 化学名称 : 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 

Smile : C(C1=CC=CC=C1)N1C(N(SC1=O)C)=O

InChiKey : JDSJDASOXWCHPN-UHFFFAOYSA-N

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同义词TDZD8; TDZD-8; TDZD 8. GSK3 Inhibitor I; NP 01139. 
英文同义词TDZD8; TDZD-8; TDZD 8. GSK3 Inhibitor I; NP 01139. 
分子式C10H10N2O2S 
分子量222.26 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC(C1=CC=CC=C1)N1C(N(SC1=O)C)=O
InChiKeyJDSJDASOXWCHPN-UHFFFAOYSA-N
InChiInChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
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TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells. 

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