T-5224
编号: 16070909
Cas号: 530141-72-1
纯度: 98% by HPLC
T-5224 is a selective inhibitor of c-Fos/activator protein-1. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T-5224 has been investigated in phase II human clinical trials. T-5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation. Accumulating evidence supports that AP-1 plays an important role in several severe disorders including cancer, fibrosis, and organ injury, as well as inflammatory disorders such as asthma, psoriasis, and rheumatoid arthritis.
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化学信息
| 名称 | T-5224 |
|---|---|
| Iupac 化学名称 | 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxybenzo[d]isoxazol-6-yl)methoxy)phenyl)propanoic acid |
| 同义词 | T5224; T-5224 |
| 英文同义词 | T5224; T-5224 |
| 分子式 | C29H27NO8 |
| 分子量 | 517.52658 |
| Smile | C1(CCCC1)OC1=CC(=C(C(=O)C=2C=CC(=C(C2)CCC(=O)O)OCC2=CC3=C(C(=NO3)O)C=C2)C=C1)O |
| InChiKey | DALCQQSLNPLQFZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33) |
| Cas号 | 530141-72-1 |
| 相关CAS号 |
订购信息
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