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T-0901317

Catalog No.: 16122840
Cas No.: 293754-55-9
Purity : 98% 
16122840 - T-0901317 | CAS 293754-55-9

Catalog number : 16122840

CAS number : 293754-55-9

分子式 : C17H12F9NO3S 

分子量 : 481.3326 

Iupac 化学名称 : T-0901317 

Smile : c1ccc(cc1)S(=O)(=O)N(CC(F)(F)F)c2ccc(cc2)C(C(F)(F)F)(C(F)(F)F)O

InChiKey : SGIWFELWJPNFDH-UHFFFAOYSA-N

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同义词TO-091317; TO 091317; TO091317; T-0901317; T-1317; TO-91317; TO 901317; T0901317; T1317; TO91317; TO901317 
英文同义词TO-091317; TO 091317; TO091317; T-0901317; T-1317; TO-91317; TO 901317; T0901317; T1317; TO91317; TO901317 
分子式C17H12F9NO3S 
分子量481.3326 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1ccc(cc1)S(=O)(=O)N(CC(F)(F)F)c2ccc(cc2)C(C(F)(F)F)(C(F)(F)F)O
InChiKeySGIWFELWJPNFDH-UHFFFAOYSA-N
InChiInChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
MDLMFCD03412028
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T-0901317, also known as T-1317; TO-091317; TO 901317, is a liver X receptor (LXR) agonist. T-0901317 inhibits development of atherosclerosis in LDL receptor-deficient mice. T-0901317 significantly reduced the atherosclerotic lesions in LDLR(-/-) mice without affecting plasma total cholesterol levels. T-0901317 increased expression of ATP binding cassette A1 in the lesions in LDLR(-/-) mice as well as in mouse peritoneal macrophages. T-0901317 also significantly induced cholesterol efflux activity in peritoneal macrophages. T-0901317 may be useful therapeutic agents for the treatment of atherosclerosis. 

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