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Sobetirome

Catalog No.: 16070907
Cas No.: 211110-63-3
Purity : 98% by HPLC 
16070907 - Sobetirome | CAS 211110-63-3

Catalog number : 16070907

CAS number : 211110-63-3

分子式 : C20H24O4 

分子量 : 328.408 

Iupac 化学名称 : 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid 

Smile : OC1=C(C=C(CC2=C(C=C(OCC(=O)O)C=C2C)C)C=C1)C(C)C

InChiKey : QNAZTOHXCZPOSA-UHFFFAOYSA-N

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同义词GC-1; GC1; GC 1; QRX-431 
英文同义词GC-1; GC1; GC 1; QRX-431 
分子式C20H24O4 
分子量328.408 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileOC1=C(C=C(CC2=C(C=C(OCC(=O)O)C=C2C)C)C=C1)C(C)C
InChiKeyQNAZTOHXCZPOSA-UHFFFAOYSA-N
InChiInChI=1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)
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Sobetirome, also known as GC-1 and QRX-431, is a hyroid hormone beta-receptor agonist. Sobetirome inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through TRalpha activation in the heart. The tissue selective thyromimetic properties of sobetirome have been demonstrated in numerous animal models, which led to its clinical development as a novel cholesterol-lowering agent. 

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