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Sepiapterin

编号: 25117
Cas号: 17094-01-8
纯度: 98% Min.

Sepiapterin is a tetrahydrobiopterin (BH4) precursor.

仅供研究使用。 我们不向患者出售。

化学信息

名称Sepiapterin
Iupac 化学名称(S)-2-amino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(1H)-one
同义词L-Sepiapterin; CNSA 001; CNSA-001; CNSA001; PTC 923; PTC-923; PTC923; Sepiapterin; Sepiapterine;
英文同义词L-Sepiapterin; CNSA 001; CNSA-001; CNSA001; PTC 923; PTC-923; PTC923; Sepiapterin; Sepiapterine;
分子式C9H11N5O3
分子量237.22
SmileO=C1N=C(N)NC2=C1N=C(C([C@@H](O)C)=O)CN2
InChiKeyVPVOXUSPXFPWBN-VKHMYHEASA-N
InChiInChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,15H,2H2,1H3,(H4,10,11,13,14,17)/t3-/m0/s1
Cas号17094-01-8
相关CAS号

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包装价格库存纯度备货期
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外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Sumi-Ichinose C, Suganuma Y, Kano T, Ikemoto K, Ihira N, Ichinose H, Kondo K. Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice. J Inherit Metab Dis. 2022 Feb 22. doi: 10.1002/jimd.12489. Epub ahead of print. PMID: 35192730.

2: Liang D, Shu R, Jiang S, Yang L, Wang Y, Zhao Y, Cai Y, Xie R, Meng Y. Identification and functional analysis of carbonyl reductases related to tetrahydrobiopterin synthesis in the silkworm, Bombyx mori. Insect Mol Biol. 2022 Feb 20. doi: 10.1111/imb.12768. Epub ahead of print. PMID: 35184330.

3: Yoshii F, Aono K, Kumazawa R, Takahashi W. PARK2 Patient Presenting with Dopa-Responsive Dystonia. Case Rep Neurol. 2021 Nov 23;13(3):749-754. doi: 10.1159/000520436. PMID: 35082644; PMCID: PMC8739933.

4: Wang W, Zheng Q, Yu C, Pan C, Luo P, Chen J. WSV056 Inhibits Shrimp Nitric Oxide Synthase Activity by Downregulating Litopenaeus vannamei Sepiapterin Reductase to Promote White Spot Syndrome Virus Replication. Front Microbiol. 2021 Dec 23;12:796049. doi: 10.3389/fmicb.2021.796049. PMID: 35003027; PMCID: PMC8733705.

5: Bratkovic D, Margvelashvili L, Tchan MC, Nisbet J, Smith N. PTC923 (sepiapterin) lowers elevated blood phenylalanine in subjects with phenylketonuria: a phase 2 randomized, multi-center, three-period crossover, open-label, active controlled, all-comers study. Metabolism. 2022 Mar;128:155116. doi: 10.1016/j.metabol.2021.155116. Epub 2021 Dec 29. PMID: 34973284.

6: Nygaard G, Szigetvari PD, Grindheim AK, Ruoff P, Martinez A, Haavik J, Kleppe R, Flydal MI. Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency. J Pers Med. 2021 Nov 12;11(11):1186. doi: 10.3390/jpm11111186. PMID: 34834538; PMCID: PMC8625014.

7: Vasquez-Vivar J, Shi Z, Tan S. Tetrahydrobiopterin in Cell Function and Death Mechanisms. Antioxid Redox Signal. 2022 Jan 27. doi: 10.1089/ars.2021.0136. Epub ahead of print. PMID: 34806400.

8: Havalı C, Dorum S, Ekici A, Görükmez Ö. Approaches for diagnosis and treatment in neurotransmitter disorders of childhood. Metab Brain Dis. 2021 Dec;36(8):2255-2262. doi: 10.1007/s11011-021-00838-w. Epub 2021 Sep 22. PMID: 34550503.

9: Lokhande RV, Dherai AJ, Bhagure GR, Udani VP, Kulkarni SD, Ashavaid TF. Cerebrospinal Fluid Biogenic Monoamine Analysis for Diagnosis of Primary Neurotransmitter Disorders. Indian J Pediatr. 2021 Dec;88(12):1241-1243. doi: 10.1007/s12098-021-03956-6. Epub 2021 Sep 20. PMID: 34541626.

10: Melo FHM, Gonçalves DA, Sousa RX, Icimoto MY, Fernandes DC, Laurindo FRM, Jasiulionis MG. Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry. Int J Mol Sci. 2021 Sep 3;22(17):9556. doi: 10.3390/ijms22179556. PMID: 34502464; PMCID: PMC8430733.

11: Gonçalves DA, Jasiulionis MG, Melo FHM. The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin. Int J Mol Sci. 2021 Sep 2;22(17):9546. doi: 10.3390/ijms22179546. PMID: 34502450; PMCID: PMC8431490.

12: Keller M, Brennenstuhl H, Kuseyri Hübschmann O, Manti F, Julia Palacios NA, Friedman J, Yıldız Y, Koht JA, Wong SN, Zafeiriou DI, López-Laso E, Pons R, Kulhánek J, Jeltsch K, Serrano-Lomelin J, Garbade SF, Opladen T, Goez H; International Working Group on Neurotransmitter related Disorders (iNTD), Burlina A, Cortès-Saladelafont E, Fernández Ramos JA, García-Cazorla A, Hoffmann GF, Kiat Hong ST, Honzík T, Kavecan I, Kurian MA, Leuzzi V, Lücke T, Manzoni F, Mastrangelo M, Mercimek-Andrews S, Mir P, Oppebøen M, Pearson TS, Sivri HS, Steel D, Stevanović G, Fung CW. Assessment of intellectual impairment, health- related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders: Data from the iNTD registry. J Inherit Metab Dis. 2021 Nov;44(6):1489-1502. doi: 10.1002/jimd.12416. Epub 2021 Aug 2. PMID: 34245036.

13: Abell TL, Garcia LM, Wiener GJ, Wo JM, Bulat RS, Smith N. Effect of Oral CNSA-001 (sepiapterin, PTC923) on gastric accommodation in women with diabetic gastroparesis: A randomized, placebo-controlled, Phase 2 trial. J Diabetes Complications. 2021 Sep;35(9):107961. doi: 10.1016/j.jdiacomp.2021.107961. Epub 2021 Jun 17. PMID: 34176722.

14: Choi H. FLIM Imaging for Metabolic Studies in Live Cells. Methods Mol Biol. 2021;2304:339-346. doi: 10.1007/978-1-0716-1402-0_18. PMID: 34028726.

15: Bozaci AE, Er E, Yazici H, Canda E, Kalkan Uçar S, Güvenc Saka M, Eraslan C, Onay H, Habif S, Thöny B, Coker M. Tetrahydrobiopterin deficiencies: Lesson from clinical experience. JIMD Rep. 2021 Feb 1;59(1):42-51. doi: 10.1002/jmd2.12199. PMID: 33977029; PMCID: PMC8100404.

16: Obeng S, Hiranita T, León F, McMahon LR, McCurdy CR. Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery. J Med Chem. 2021 May 27;64(10):6523-6548. doi: 10.1021/acs.jmedchem.1c00028. Epub 2021 May 6. Erratum in: J Med Chem. 2021 Aug 12;64(15):11746. PMID: 33956427.

17: Furukawa Y, Tomizawa Y, Nakahara T. Neurometabolic causes of dystonia: Sepiapterin reductase-deficient dopamine- and serotonin-responsive dystonia-plus syndrome. J Neurol Sci. 2021 Jun 15;425:117468. doi: 10.1016/j.jns.2021.117468. Epub 2021 Apr 21. PMID: 33926741.

18: Himmelreich N, Blau N, Thöny B. Molecular and metabolic bases of tetrahydrobiopterin (BH4) deficiencies. Mol Genet Metab. 2021 Jun;133(2):123-136. doi: 10.1016/j.ymgme.2021.04.003. Epub 2021 Apr 19. PMID: 33903016.

19: Phua CS, Kumar KR, Levy S. Reply to: Neurometabolic causes of dystonia: Sepiapterin reductase-deficient dopamine- and serotonin-responsive dystonia-plus syndrome. J Neurol Sci. 2021 Jun 15;425:117469. doi: 10.1016/j.jns.2021.117469. Epub 2021 Apr 21. PMID: 33902913.

20: Rabender CS, Mezzaroma E, Yakovlev VA, Mauro AG, Bonaventura A, Abbate A, Mikkelsen RB. Mitigation of Radiation-Induced Lung and Heart Injuries in Mice by Oral Sepiapterin after Irradiation. Radiat Res. 2021 May 1;195(5):463-473. doi: 10.1667/RADE-20-00249.1. PMID: 33822229; PMCID: PMC8162938.

化学结构

25117 - Sepiapterin | CAS 17094-01-8

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