STC-15
STC-15 is a first-in-class inhibitor of RNA modification and is the first ever RNA methyltransferase inhibitor to enter clinical development. STC-15 is an oral small molecule that inhibits METTL3, an RNA methyltransferase implicated in oncology and other diseases. Certain RNA methyltransferases are important regulators of RNA sensing and innate immune activation and represent novel immune-regulatory targets.
STC-15 has also been shown to inhibit tumor growth through mechanisms involving anti-cancer immune responses such as changes in interferon signaling and synergy with T cell checkpoint blockade. In addition, this compound, has demonstrated efficacy in leukemia models via mechanisms such as inhibition of leukemia stem cell function.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | STC-15 |
|---|---|
| Iupac 化学名称 | N-((2-(((cyclobutylmethyl)amino)methyl)-1H-indol-6-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide |
| 同义词 | STC-15; STC15 ; STC 15 |
| 英文同义词 | STC-15; STC15 ; STC 15 |
| 分子式 | C24H25N5O2 |
| 分子量 | 415.49 |
| Smile | O=C(C(N=C3N2C=CC=C3)=CC2=O)NCC4=CC1=C(C=C4)C=C(CNCC5CCC5)N1 |
| InChiKey | MFQFZLWCFZZHAI-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H25N5O2/c30-23-12-21(28-22-6-1-2-9-29(22)23)24(31)26-14-17-7-8-18-11-19(27-20(18)10-17)15-25-13-16-4-3-5-16/h1-2,6-12,16,25,27H,3-5,13-15H2,(H,26,31) |
| Cas号 | 2648257-56-9 |
| 相关CAS号 | 2648257-56-9 |
订购信息
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