STC-15
STC-15 is a first-in-class inhibitor of RNA modification and is the first ever RNA methyltransferase inhibitor to enter clinical development. STC-15 is an oral small molecule that inhibits METTL3, an RNA methyltransferase implicated in oncology and other diseases. Certain RNA methyltransferases are important regulators of RNA sensing and innate immune activation and represent novel immune-regulatory targets.
STC-15 has also been shown to inhibit tumor growth through mechanisms involving anti-cancer immune responses such as changes in interferon signaling and synergy with T cell checkpoint blockade. In addition, this compound, has demonstrated efficacy in leukemia models via mechanisms such as inhibition of leukemia stem cell function.
仅供研究使用。 我们不向患者出售。
Chemical Information
| Name | STC-15 |
|---|---|
| Iupac Chemical Name | N-((2-(((cyclobutylmethyl)amino)methyl)-1H-indol-6-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide |
| Synonyms | STC-15; STC15 ; STC 15 |
| 英文同义词 | STC-15; STC15 ; STC 15 |
| Molecular Formula | C24H25N5O2 |
| Molecular Weight | 415.49 |
| Smile | O=C(C(N=C3N2C=CC=C3)=CC2=O)NCC4=CC1=C(C=C4)C=C(CNCC5CCC5)N1 |
| InChiKey | MFQFZLWCFZZHAI-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H25N5O2/c30-23-12-21(28-22-6-1-2-9-29(22)23)24(31)26-14-17-7-8-18-11-19(27-20(18)10-17)15-25-13-16-4-3-5-16/h1-2,6-12,16,25,27H,3-5,13-15H2,(H,26,31) |
| CAS Number | 2648257-56-9 |
| 相关CAS号 | 2648257-56-9 |
Ordering Information
| 包装 | Price | 库存 | Purity | 备货期 |
|---|---|---|---|---|
| 大货 | Enquiry | Enquiry | Enquiry |
| 外观性状 | Off-white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| 处理方式 | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 | 2934200090 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
