SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested
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化学信息
| 名称 | SMI-4a |
| Iupac 化学名称 | (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| 分子式 | C11H6F3NO2S |
| 分子量 | 273.23 |
| Smile | O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2 |
| InChiKey | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| InChi | InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
| Cas号 | 438190-29-5 |
| 相关CAS号 | |
| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder 6 months-80ºCin solvent |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature |
| 海关编码 | |
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| Mechanism | |
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