SMER28 is a small molecule modulator of autophagy, inducing autophagy independently of rapamycin in mammalian cells. SMER28, acting via an mTOR-independent mechanism, prevented the accumulation of amyloid beta peptide within these cells. SMER28 may have therapeutic potential for the treatment of Alzheimer's disease and other proteinopathies.
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化学信息
| 名称 | SMER28 |
| Iupac 化学名称 | 6-bromo-N-2-propen-1-yl-4-quinazolinamine |
| 同义词 | SMER-28; SMER 28 |
| 英文同义词 | SMER-28; SMER 28 |
| 分子式 | C11H10BrN3 |
| 分子量 | 264.126 |
| Smile | BrC=1C=C2C(=NC=NC2=CC1)NCC=C |
| InChiKey | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
| InChi | InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15) |
| Cas号 | 307538-42-7 |
| 相关CAS号 | |
| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |