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SKF-91488 HCl

编号: 20662
Cas号: 68941-21-9
纯度: 98% Min.

SKF 91488 dihydrochloride is a homolog of dimaprit.

仅供研究使用。 我们不向患者出售。

化学信息

名称SKF-91488 HCl
Iupac 化学名称4-(dimethylamino)butyl carbamimidothioate dihydrochloride
同义词SKF 91488 dihydrochloride; SKF 91488 HCl; SKF91488 HCl; SKF 91488 dihydrochloride
英文同义词SKF 91488 dihydrochloride; SKF 91488 HCl; SKF91488 HCl; SKF 91488 dihydrochloride
分子式C7H19Cl2N3S
分子量248.22
SmileCN(CCCCSC(=N)N)C.Cl.Cl
InChiKeyNPLHSMBWWIIWAQ-UHFFFAOYSA-N
InChiInChI=1S/C7H17N3S.2ClH/c1-10(2)5-3-4-6-11-7(8)9;;/h3-6H2,1-2H3,(H3,8,9);2*1H
Cas号68941-21-9
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状固体粉末
纯度98% Min.
存储短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
可溶性溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Jochem J, Zwirska-Korczala K, Rybus-Kalinowska B, Jagodzińska J, Korzonek-
Szlacheta I. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on
the central cardiovascular regulation during controlled, stepwise hemorrhagic
hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54(3):237-44. PMID: 12398155.

2: Malmberg-Aiello P, Lamberti C, Ipponi A, Hänninen J, Ghelardini C, Bartolini
A. Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301
U, in rodent antinociception. Naunyn Schmiedebergs Arch Pharmacol. 1997
Mar;355(3):354-60. doi: 10.1007/pl00004954. PMID: 9089666.

3: Jochem J. Endogenous central histamine-induced reversal of critical
haemorrhagic hypotension in rats--studies with histamine N-methyltransferase
inhibitor SKF 91488. Inflamm Res. 2002 Nov;51(11):551-6. doi:
10.1007/pl00012426. PMID: 12540019.

4: Klein MC, Gertner SB. Evidence for a role of endogenous histamine in central
cardiovascular regulation: inhibition of histamine-N-methyltransferase by SKF
91488. J Pharmacol Exp Ther. 1981 Feb;216(2):315-20. PMID: 6450831.

5: Nakazawa H, Sekizawa K, Morikawa M, Yamauchi K, Satoh M, Maeyama K, Watanabe
T, Sasaki H. Viral respiratory infection causes airway hyperresponsiveness and
decreases histamine N-methyltransferase activity in guinea pigs. Am J Respir
Crit Care Med. 1994 May;149(5):1180-5. doi: 10.1164/ajrccm.149.5.8173757. PMID:
8173757.

化学结构

20662 - SKF-91488 HCl | CAS 68941-21-9

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