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SIS3

编号: 16122721
Cas号: 521984-48-5
纯度: 98% 

SIS3, a novel specific inhibitor of Smad3, inhibits TGF- and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. SIS3 also inhibits the myofibroblast differentiation of fibroblasts by TGF-1. SIS3 completely diminishes the constitutive phosphorylation of Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts, thus abolishes the ECM overexpression in the TGF-1-treated normal dermal fibroblasts and scleroderma fibroblasts in vitro 

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化学信息

名称SIS3
Iupac 化学名称SIS3 
同义词N/A 
英文同义词N/A 
分子式C28H27N3O3.HCl 
分子量489.99 
SmileCn1c(c(c2c1nccc2)/C=C/C(=O)N3CCc4cc(c(cc4C3)OC)OC)c5ccccc5.Cl
InChiKeyCDKIEBFIMCSCBB-CALJPSDSSA-N
InChiInChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
Cas号521984-48-5
MDLMFCD09265258
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122721 - SIS3 | CAS 521984-48-5

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