SHP099 free base
编号: 17030107
Cas号: 1801747-42-1
纯度: 98%
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 M and p-ERK modulation in cells IC50 = 0.250 M. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1).
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | SHP099 free base |
|---|---|
| Iupac 化学名称 | SHP099 free base |
| 同义词 | SHP099; SHP-099; SHP 099 |
| 英文同义词 | SHP099; SHP-099; SHP 099 |
| 分子式 | C16H19Cl2N5 |
| 分子量 | 352.263 |
| InChiKey | |
| InChi | |
| Cas号 | 1801747-42-1 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
