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SB-216763

Catalog No.: 161009026
Cas No.: 280744-09-4
Purity : 98% by HPLC 
161009026 - SB-216763 | CAS 280744-09-4

Catalog number : 161009026

CAS number : 280744-09-4

分子式 : C19H12Cl2N2O2 

分子量 : 371.22 

Iupac 化学名称 : 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 

Smile : ClC1=C(C=CC(=C1)Cl)C=1C(NC(C1C1=CN(C2=CC=CC=C12)C)=O)=O

InChiKey : JCSGFHVFHSKIJH-UHFFFAOYSA-N

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同义词SB216763; SB 216763; SB216763 
英文同义词SB216763; SB 216763; SB216763 
分子式C19H12Cl2N2O2 
分子量371.22 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC1=C(C=CC(=C1)Cl)C=1C(NC(C1C1=CN(C2=CC=CC=C12)C)=O)=O
InChiKeyJCSGFHVFHSKIJH-UHFFFAOYSA-N
InChiInChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
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SB-216763 is a glycogen synthase kinase-3 (GSK3) inhibitor, which can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). SB-216763 is the first GSK3 inhibitor that can promote self-renewal of mESC co-cultured with MEFs for more than two months. 

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