SAR407899 HCl
编号: 17011606
Cas号: 923262-96-8
纯度: 98%
SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity. SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. SAR407899 is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. SAR407899 is approximately 8-fold more active than fasudil. SAR407899 potently (mean IC(50) values: 122 to 280 nM) and species-independently relaxed precontracted isolated arteries of different species and different vascular beds. The antihypertensive effect of SAR407899 was superior to that of fasudil and Y-27632.
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化学信息
| 名称 | SAR407899 HCl |
|---|---|
| Iupac 化学名称 | 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride |
| 同义词 | SAR 407899; SAR-407899; SAR407899 HCl |
| 英文同义词 | SAR 407899; SAR-407899; SAR407899 HCl |
| 分子式 | C14H17ClN2O2 |
| 分子量 | 280.752 |
| Smile | Cl.N1CCC(CC1)OC=1C=C2C=CNC(C2=CC1)=O |
| InChiKey | KMNVOGVCCZNVNU-UHFFFAOYSA-N |
| InChi | InChI=1S/C14H16N2O2.ClH/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11;/h1-3,8-9,11,15H,4-7H2,(H,16,17);1H |
| Cas号 | 923262-96-8 |
| 相关CAS号 |
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