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SAG(Smo-Agonist)

Catalog No.: 92802
Cas No.: 912545-86-9
Purity : 99.03% by HPLC at 254nm 
92802 - SAG(Smo-Agonist) | CAS 912545-86-9

Catalog number : 92802

CAS number : 912545-86-9

分子式 : C28H28ClN3OS 

分子量 : 490.06 

Iupac 化学名称 : 3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide 

Smile : O=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4

InChiKey : VFSUUTYAEQOIMW-YHBQERECSA-N

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分子式C28H28ClN3OS 
分子量490.06 
外观light yellow solid 
纯度99.03% by HPLC at 254nm 
可溶性Soluble in DMSO to 20 mM 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4
InChiKeyVFSUUTYAEQOIMW-YHBQERECSA-N
InChiInChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
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SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins.

 

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