S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L.
S49076 potently blocks cellular phosphorylation of MET, AXL, and FGFRs and inhibits downstream signaling in vitro and in vivo. In cell models, S49076 inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. S49076 inhibits viability, motility, and three-dimensional colony formation of cancer cells expressing MET, AXL, or FGFRs.
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名称 | S49076 |
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Iupac 化学名称 | S49076 |
同义词 | N/A |
英文同义词 | N/A |
分子式 | C22H22N4O4S |
分子量 | 438.50 |
InChiKey | |
InChi | |
Cas号 | 1265965-22-7 |
相关CAS号 |
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