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Resatorvid

编号: 206102
Cas号: 243984-11-4
纯度: 98% Min.

 Resatorvid, also known as TAK-242, is a cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Resatorvid binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Resatorvid provides neuroprotection in experimental traumatic brain injury: implication in the treatment of human brain injury.


仅供研究使用。 我们不向患者出售。

化学信息

名称Resatorvid
Iupac 化学名称ethyl (R)-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate
同义词 TAK-242; TAK 242; TAK242; Resatorvid
英文同义词 TAK-242; TAK 242; TAK242; Resatorvid
分子式C15H17ClFNO4S
分子量361.8124
SmileFC1=CC(Cl)=C(NS([C@@H]2CCCC=C2C(OCC)=O)(=O)=O)C=C1
InChiKeyLEEIJTHMHDMWLJ-CQSZACIVSA-N
InChi InChI=1S/C15H17ClFNO4S/c1-2-22-15(19)11-5-3-4-6-14(11)23(20,21)18-13-8-7-10(17)9-12(13)16/h5,7-9,14,18H,2-4,6H2,1H3/t14-/m1/s1
Cas号243984-11-4
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状固体粉末
纯度98% Min.
存储干燥、黑暗,短期(日至周)0-4摄氏度,长期(月至年)0-20摄氏度。
可溶性可溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Feng Y, Gao J, Cui Y, Li M, Li R, Cui C, Cui J. Neuroprotective Effects of
Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal
Autophagy and TLR4 Signaling Pathway. Cell Mol Neurobiol. 2016 Mar 10. [Epub
ahead of print] PubMed PMID: 26961544.

2: Zhang D, Li H, Li T, Zhou M, Hao S, Yan H, Yu Z, Li W, Li K, Hang C. TLR4
inhibitor resatorvid provides neuroprotection in experimental traumatic brain
injury: implication in the treatment of human brain injury. Neurochem Int. 2014
Sep;75:11-8. doi: 10.1016/j.neuint.2014.05.003. Epub 2014 May 20. PubMed PMID:
24858944.

3: Takeuchi T, Jinno F, Ebihara T, Moriya Y, Kadotani R, Tagawa Y, Kondo T, Itoh
T, Asahi S. Species differences of organic anion transporters involved in the
renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of
resatorvid, between rats and dogs. Biopharm Drug Dispos. 2013 May;34(4):236-46.
doi: 10.1002/bdd.1841. Epub 2013 May 7. PubMed PMID: 23529922.

4: Jinno F, Takeuchi T, Tagawa Y, Kondo T, Itoh T, Asahi S. Differences in the
pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of
resatorvid, in rats and dogs. Drug Metab Dispos. 2012 Apr;40(4):648-54. doi:
10.1124/dmd.111.043729. Epub 2011 Dec 27. PubMed PMID: 22203697.

5: Matsunaga N, Tsuchimori N, Matsumoto T, Ii M. TAK-242 (resatorvid), a
small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds
selectively to TLR4 and interferes with interactions between TLR4 and its adaptor
molecules. Mol Pharmacol. 2011 Jan;79(1):34-41. doi: 10.1124/mol.110.068064. Epub
2010 Sep 29. PubMed PMID: 20881006.


化学结构

206102 - Resatorvid | CAS 243984-11-4

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