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RGB-286638 free base

Catalog No.: 122917
Cas No.: 784210-88-4
Purity : 98% 
122917 - RGB-286638 free base | CAS 784210-88-4

Catalog number : 122917

CAS number : 784210-88-4

分子式 : C29H35N7O4 

分子量 : 545.633 

Iupac 化学名称 : 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea 

Smile : COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6

InChiKey : XLSYZSRXVVCHLS-UHFFFAOYSA-N

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同义词RGB286638 
英文同义词RGB286638 
分子式C29H35N7O4 
分子量545.633 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCOCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6
InChiKeyXLSYZSRXVVCHLS-UHFFFAOYSA-N
InChiInChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)
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RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
 

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