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Q-VD-OPH

Catalog No.: 16071010
Cas No.: 1135695-98-5
Purity : 98% by HPLC 
16071010 - Q-VD-OPH | CAS 1135695-98-5

Catalog number : 16071010

CAS number : 1135695-98-5

分子式 : C26H25F2N3O6 

分子量 : 513.8 

Iupac 化学名称 : (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-Methyl-1-oxo-2-[(2-quinolinylcarbonyl)aMino]butyl]aMino]-4-oxo-pentanoic Acid 

Smile : FC1=C(OCC([C@H](CC(=O)O)NC([C@H](C(C)C)NC(=O)C2=NC3=CC=CC=C3C=C2)=O)=O)C(=CC=C1)F

InChiKey : OOBJCYKITXPCNS-REWPJTCUSA-N

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同义词Q-VD-OPH 
英文同义词Q-VD-OPH 
分子式C26H25F2N3O6 
分子量513.8 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileFC1=C(OCC([C@H](CC(=O)O)NC([C@H](C(C)C)NC(=O)C2=NC3=CC=CC=C3C=C2)=O)=O)C(=CC=C1)F
InChiKeyOOBJCYKITXPCNS-REWPJTCUSA-N
InChiInChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1
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Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). It protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated. 

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