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Pluripotin(SC-1)

Catalog No.: 100502
Cas No.: 839707-37-8
Purity : 98% by HPLC 
100502 - Pluripotin(SC-1) | CAS 839707-37-8

Catalog number : 100502

CAS number : 839707-37-8

分子式 : C27H25F3N8O2 

分子量 : 550.54621 

Iupac 化学名称 : N-(3-(7-((1,3-dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide 

Smile : O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC(C)=NN4C)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5

InChiKey : NBZFRTJWEIHFPF-UHFFFAOYSA-N

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同义词Pluripotin,SC-1,SC1,SC 1 
英文同义词Pluripotin,SC-1,SC1,SC 1 
分子式C27H25F3N8O2 
分子量550.54621 
外观crystalline solid 
纯度98% by HPLC 
可溶性Soluble in DMSO to 20 mM 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC(C)=NN4C)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
InChiKeyNBZFRTJWEIHFPF-UHFFFAOYSA-N
InChiInChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
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SC1 (Pluripotin) was identified in a cell-based chemical  library screen for small   molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo.  

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