Pexidartinib
编号: 52753
Cas号: 1029044-16-3
纯度: 98%
- pexidartinib is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Pexidartinib binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Pexidartinib |
|---|---|
| Iupac 化学名称 | 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine |
| 同义词 | PLX3397; PLX-3397; PLX 3397; Pexidartinib |
| 英文同义词 | PLX3397; PLX-3397; PLX 3397; Pexidartinib |
| 分子式 | C20H15ClF3N5 |
| 分子量 | 417.81 |
| Smile | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F |
| InChiKey | JGWRKYUXBBNENE-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29) |
| Cas号 | 1029044-16-3 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
