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Pexidartinib

Catalog No.: 52753
Cas No.: 1029044-16-3
Purity : 98% 
52753 - Pexidartinib | CAS 1029044-16-3

Catalog number : 52753

CAS number : 1029044-16-3

分子式 : C20H15ClF3N5 

分子量 : 417.81 

Iupac 化学名称 : 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

Smile : FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F

InChiKey : JGWRKYUXBBNENE-UHFFFAOYSA-N

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同义词PLX3397; PLX-3397; PLX 3397; Pexidartinib
英文同义词PLX3397; PLX-3397; PLX 3397; Pexidartinib
分子式C20H15ClF3N5 
分子量417.81 
外观 类白色至白色固体
纯度98% 
可溶性10 mM in DMSO 
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
SmileFC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
InChiKeyJGWRKYUXBBNENE-UHFFFAOYSA-N
InChiInChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
pexidartinib is a
 capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Pexidartinib binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis. 


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