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Pevonedistat

Catalog No.: 16071408
Cas No.: 905579-51-3
Purity : 98% by HPLC 
16071408 - Pevonedistat | CAS 905579-51-3

Catalog number : 16071408

CAS number : 905579-51-3

分子式 : C21H25N5O4S 

分子量 : 443.52 

Iupac 化学名称 : ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate 

Smile : S(N)(OC[C@H]1[C@H](C[C@@H](C1)N1C=CC2=C1N=CN=C2N[C@H]2CCC1=CC=CC=C21)O)(=O)=O

InChiKey : MPUQHZXIXSTTDU-QXGSTGNESA-N

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同义词TAK-924; TAK 924; 
英文同义词TAK-924; TAK 924; 
分子式C21H25N5O4S 
分子量443.52 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileS(N)(OC[C@H]1[C@H](C[C@@H](C1)N1C=CC2=C1N=CN=C2N[C@H]2CCC1=CC=CC=C21)O)(=O)=O
InChiKeyMPUQHZXIXSTTDU-QXGSTGNESA-N
InChiInChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
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Pevonedistat, also known as MLN-4924 and TAK-924, is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP).

 

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