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PRX-08066

编号: 16071114
Cas号: 866206-54-4
纯度: 98% by HPLC 

PRX-08066 is a a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. In the 5-HT(2B) expressing SI-NET cell line, KRJ-I, PRX-08066 inhibited proliferation (IC(50) 4.6 x 10(-9)M) and 5-HT secretion (6.9 x 10(-9)M) and decreased ERK1/2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1], connective tissue growth factor [CTGF] and fibroblast growth factor [FGF2]). 

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化学信息

名称PRX-08066
Iupac 化学名称5-((4-(6-Chlorothieno(2,3-d)pyrimidine-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile 
同义词PRX-08066; PRX 08066 
英文同义词PRX-08066; PRX 08066 
分子式C19H17ClFN5S 
分子量401.8884 
SmileClC1=CC2=C(N=CN=C2NC2CCN(CC2)CC=2C=CC(=C(C#N)C2)F)S1
InChiKeyIENZFHBNCRQMNP-UHFFFAOYSA-N
InChiInChI=1S/C19H17ClFN5S/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25)
Cas号866206-54-4
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状Solid powder 
纯度98% by HPLC 
存储-20 ºC for 3 years 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16071114 - PRX-08066 | CAS 866206-54-4

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