PLX8394
编号: 20613
Cas号: 1393466-87-9
纯度: 98% Min.
PLX8394 is an orally bioavailable inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential antineoplastic activity. PLX8394 appears to selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, which may subsequently inhibit the proliferation of tumor cells which express mutated forms of BRAF. PLX8394 appears to be effective against tumors that express multiple mutated forms of the kinase and may be an effective therapeutic agent for tumors that are resistant to other BRAF inhibitor therapies that are specific for the BRAF V600E mutant.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | PLX8394 |
|---|---|
| Iupac 化学名称 | (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide |
| 同义词 | PLX8394; PLX-8394; PLX 8394, |
| 英文同义词 | PLX8394 ; PLX-8394; PLX 8394, |
| 分子式 | C25H21F3N6O3S |
| 分子量 | 542.53 |
| Smile | O=S(N1C[C@H](F)CC1)(NC2=CC=C(F)C(C(C3=CNC4=NC=C(C5=CN=C(C6CC6)N=C5)C=C43)=O)=C2F)=O |
| InChiKey | YYACLQUDUDXAPA-MRXNPFEDSA-N |
| InChi | InChI=1S/C25H21F3N6O3S/c26-16-5-6-34(12-16)38(36,37)33-20-4-3-19(27)21(22(20)28)23(35)18-11-32-25-17(18)7-14(8-31-25)15-9-29-24(30-10-15)13-1-2-13/h3-4,7-11,13,16,33H,1-2,5-6,12H2,(H,31,32)/t16-/m1/s1 |
| Cas号 | 1393466-87-9 |
| 相关CAS号 | 1393466-87-9 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
_1393466-87-9.png)