PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
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化学信息
| 名称 | PLX7904 |
| Iupac 化学名称 | PLX7904 |
| 同义词 | PB04 |
| 英文同义词 | PB04 |
| 分子式 | C24H22F2N6O3S |
| 分子量 | 512.53 |
| InChiKey | |
| InChi | |
| Cas号 | 1393465-84-3 |
| 相关CAS号 | |
| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |