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PLX-4720

Catalog No.: 52592
Cas No.: 918505-84-7
Purity : 98% 
52592 - PLX-4720 | CAS 918505-84-7

Catalog number : 52592

CAS number : 918505-84-7

分子式 : C17H14ClF2N3O3S 

分子量 : 413.83 

化学名称 : PLX-4720

Smile : CCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c2c[nH]c3c2cc(cn3)Cl)F

InChiKey : YZDJQTHVDDOVHR-UHFFFAOYSA-N

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分子式C17H14ClF2N3O3S 
分子量413.83 
纯度98% 
SmileCCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c2c[nH]c3c2cc(cn3)Cl)F
InChiKeyYZDJQTHVDDOVHR-UHFFFAOYSA-N
InChiInChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
MDLMFCD14635203
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PLX 4720 is a potent and selective inhibitor of B-RafV600E(IC50=13 nM) and c-Raf-1Y340D/Y341D(IC50=6.7 nM); 10-fold selectivity for B-RafV600E than wild-type B-Raf. 

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