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PKI-587

Catalog No.: 73109
Cas No.: 1197160-78-3
Purity : 97% 
73109 - PKI-587 | CAS 1197160-78-3

Catalog number : 73109

CAS number : 1197160-78-3

分子式 : C32H41N9O4 

分子量 : 615.73 

Iupac 化学名称 : 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea 

Smile : CN(C1CCN(CC1)C(=O)C1=CC=C(C=C1)NC(=O)NC1=CC=C(C=C1)C1=NC(=NC(=N1)N1CCOCC1)N1CCOCC1)C

InChiKey : DWZAEMINVBZMHQ-UHFFFAOYSA-N

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同义词PF-05212384; PF5212384; PF05212384; PF 05212384; Gedatolisib 
英文同义词PF-05212384; PF5212384; PF05212384; PF 05212384; Gedatolisib 
分子式C32H41N9O4 
分子量615.73 
外观White solid powder 
纯度97% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCN(C1CCN(CC1)C(=O)C1=CC=C(C=C1)NC(=O)NC1=CC=C(C=C1)C1=NC(=NC(=N1)N1CCOCC1)N1CCOCC1)C
InChiKeyDWZAEMINVBZMHQ-UHFFFAOYSA-N
InChiInChI=1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)
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PKI-587 is a potent inhibitor to PI3K-, PI3K-, and mTOR (FRAP) with IC50 of 0.4 nM, 5.4 nM, and 1.6 nM, respectively. PKI-587 also exhibits potency against the most frequently occurring mutant forms of PI3K, notably the H1047R and E545K with IC50 of 0.6 nM and 0.6 nM, respectively. PF-05212384 inhibitory actions against PI3Ks and mTORs causes tumor cell growth inhibition in MDA-361 and PC3-MM2 cell lines with IC50 of 4 nM and 13.1 nM, respectively. 

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