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PI-103

Catalog No.: 160926002
Cas No.: 371935-74-9
Purity : 97% by HPLC 
160926002 - PI-103 | CAS 371935-74-9

Catalog number : 160926002

CAS number : 371935-74-9

分子式 : C19H16N4O3 

分子量 : 348.4 

Iupac 化学名称 : 3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol 

Smile : N1(CCOCC1)C=1C2=C(N=C(N1)C=1C=C(C=CC1)O)C1=C(O2)N=CC=C1

InChiKey : TUVCWJQQGGETHL-UHFFFAOYSA-N

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同义词3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V 
英文同义词3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V 
分子式C19H16N4O3 
分子量348.4 
外观Solid powder 
纯度97% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileN1(CCOCC1)C=1C2=C(N=C(N1)C=1C=C(C=CC1)O)C1=C(O2)N=CC=C1
InChiKeyTUVCWJQQGGETHL-UHFFFAOYSA-N
InChiInChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
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 It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 M. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 l) solution of PI-103  in DMSO is also available.
 

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