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PFI-4

Catalog No.: 82406
Cas No.: 900305-37-5
Purity : 98% 
82406 - PFI-4 | CAS 900305-37-5

Catalog number : 82406

CAS number : 900305-37-5

分子式 : C21H24N4O3 

分子量 : 380.44 

Iupac 化学名称 : N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide 

Smile : CN1C(N(C2=C1C=C(C(=C2)NC(C2=C(C=CC=C2)OC)=O)N2CCCC2)C)=O

InChiKey : QCIJLRJBZDBVDB-UHFFFAOYSA-N

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同义词PFI4��PFI 4 
英文同义词PFI4��PFI 4 
分子式C21H24N4O3 
分子量380.44 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCN1C(N(C2=C1C=C(C(=C2)NC(C2=C(C=CC=C2)OC)=O)N2CCCC2)C)=O
InChiKeyQCIJLRJBZDBVDB-UHFFFAOYSA-N
InChiInChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
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PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 binding to histone H3.3. Cell permeable. 

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