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PF-573228

Catalog No.: 52816
Cas No.: 869288-64-2
Purity : 98% 
52816 - PF-573228 | CAS 869288-64-2

Catalog number : 52816

CAS number : 869288-64-2

分子式 : C22H20F3N5O3S 

分子量 : 491.49 

化学名称 : PF-573228

Smile : CS(=O)(=O)c1cccc(c1)CNc2c(cnc(n2)Nc3ccc4c(c3)CCC(=O)N4)C(F)(F)F

InChiKey : HESLKTSGTIBHJU-UHFFFAOYSA-N

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分子式C22H20F3N5O3S 
分子量491.49 
纯度98% 
可溶性DMSO 50 mg/ml 
SmileCS(=O)(=O)c1cccc(c1)CNc2c(cnc(n2)Nc3ccc4c(c3)CCC(=O)N4)C(F)(F)F
InChiKeyHESLKTSGTIBHJU-UHFFFAOYSA-N
InChiInChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)
MDLMFCD11519967
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PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK; inhibits FAK phosphorylation on Tyr(397) with an IC(50) of 30-100 nM. 

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