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PF-5274857

Catalog No.: 010423
Cas No.: 1373615-35-0
Purity : 98% 
010423 - PF-5274857 | CAS 1373615-35-0

Catalog number : 010423

CAS number : 1373615-35-0

分子式 : C20H25ClN4O3S 

分子量 : 436.956 

Iupac 化学名称 : 1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one 

Smile : CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C

InChiKey : BBVNTTZIOTWDSV-UHFFFAOYSA-N

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同义词PF 5274857; PF5274857 
英文同义词PF 5274857; PF5274857 
分子式C20H25ClN4O3S 
分子量436.956 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
InChiKeyBBVNTTZIOTWDSV-UHFFFAOYSA-N
InChiInChI=1S/C20H25ClN4O3S/c1-14-10-15(2)20(23-12-14)16-11-18(22-13-17(16)21)24-5-7-25(8-6-24)19(26)4-9-29(3,27)28/h10-13H,4-9H2,1-3H3
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PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the bloodCbrain barrier. 

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