PF-4989216
编号: 161009002
Cas号: 1276553-09-3
纯度: 98% by HPLC
PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | PF-4989216 |
|---|---|
| Iupac 化学名称 | 4-(4-cyano-2-fluorophenyl)-2-morpholino-5-(1H-1,2,4-triazol-5-yl)thiophene-3-carbonitrile |
| 同义词 | PF4989216; PF 4989216; PF-4989216. |
| 英文同义词 | PF4989216; PF 4989216; PF-4989216. |
| 分子式 | C18H13FN6OS |
| 分子量 | 380.39882 |
| Smile | C(#N)C1=CC(=C(C=C1)C=1C(=C(SC1C1=NC=NN1)N1CCOCC1)C#N)F |
| InChiKey | MUENOTXSRZEFJV-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H13FN6OS/c19-14-7-11(8-20)1-2-12(14)15-13(9-21)18(25-3-5-26-6-4-25)27-16(15)17-22-10-23-24-17/h1-2,7,10H,3-6H2,(H,22,23,24) |
| Cas号 | 1276553-09-3 |
| 相关CAS号 |
订购信息
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