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ONO-4059盐酸盐

Catalog No.: 17012103
Cas No.: 1439901-97-9
Purity : 98% 

ONO-4059是BTK的选择性和新型抑制剂,IC50为2.2 nm,ONO - 4059与B细胞内的BTK结合,从而阻止B细胞受体信号传导,阻碍B细胞的发育。

For research use only. We do not sell to patients.

Chemical Information

名称ONO-4059盐酸盐
Iupac 化学名称(R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride
同义词ONO-4059 HCl ; ONO4059 ; ONO 4059 ; ONO-4059 ; GS 4059 ; GS-4059 ; GS4059 ; ONO-WG-307 ; Tirabrutinib
英文同义词ONO-4059 HCl ; ONO4059 ; ONO 4059 ; ONO-4059 ; GS 4059 ; GS-4059 ; GS4059 ; ONO-WG-307 ; Tirabrutinib
分子式C₂₅H₂₃ClN₆O₃ 
分子量490.94 
SmileO=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5.[H]Cl
InChiKeyUQYDCIJFACDXSG-GMUIIQOCSA-N
InChiInChI=1S/C25H22N6O3.ClH/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19;/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28);1H/t18-;/m1./s1
Cas号1439901-97-9
Related CAS1439901-97-9 (HCl) 1351636-18-4 (free base)

Ordering Information

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Formulation类白色至白色固体
纯度98% 
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO
Handling
运输条件可在常温下运输
HS Code
Coming soon.
TargetsBTK inhibitor
MechanismONO-4059 is a selective and novel inhibitor of BTK with IC50 2.2 nm, ONO-4059 binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
Cell study
Animal study
Clinical study
Not available

化学结构

17012103 - ONO-4059盐酸盐 | CAS 1439901-97-9

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