OICR-9429
编号: 6111010
Cas号: 1801787-56-3
纯度: 98%
OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . target: Wdr5 IC 50: 5 uM In vitro: OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5. [1] reduce the viability of primary human AML cells with N-terminal C/EBP mutations by about 50% (mean value, n = 8) at 5 M [2] In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | OICR-9429 |
|---|---|
| Iupac 化学名称 | OICR-9429 |
| 同义词 | OICR9429, OICR 9429 |
| 英文同义词 | OICR9429, OICR 9429 |
| 分子式 | C29H32F3N5O3 |
| 分子量 | 555.59 |
| InChiKey | |
| InChi | |
| Cas号 | 1801787-56-3 |
| 相关CAS号 |
订购信息
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