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OATD-01

Catalog No.: 208191
Cas No.: 2088453-21-6
Purity : ≧98.0%

OATD-01Bulk in stockcontact us by email for the Bulk quotation.

OATD-01是一种有效的酸性哺乳动物几丁质酶(AMCase)和壳三糖苷酶(CHIT1)双重抑制剂,hAMCase IC50 = 9nM,hCHIT1 IC50 = 26nM,m AMCase IC50 = 8nM,hCHIT1 IC50 = 29nM。 OATD-01可以显着改善博来霉素诱导的小鼠模型中的肺纤维化。 OATD-01是针对几丁质酶家族成员的第一个进入临床研究的候选药物。

For research use only. We do not sell to patients.

Chemical Information

名称OATD-01
Iupac 化学名称5-[4-[(2S,5S)-5-[(4-Chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine
同义词OATD-01; OATD 01; OATD01;
英文同义词OATD-01; OATD 01; OATD01;
分子式C19H27ClN6O
分子量390.91
SmileNC1=NNC(N2CCC(N3C[C@H](C)OC[C@@H]3CC4=CC=C(Cl)C=C4)CC2)=N1
InChiKeySTWVLEKJQQRGMO-GUYCJALGSA-N
InChiInChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1
Cas号2088453-21-6
Related CAS2088453-21-6

Ordering Information

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Formulation类白色至白色固体
纯度≧98.0%
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
运输条件可在常温下运输
HS Code
Coming soon.
TargetsDual Chitinase Inhibitor
MechanismOATD-01 is a potent dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with hAMCase IC50=9nM, hCHIT1 IC50=26nM, m AMCase IC50=8nM, hCHIT1 IC50=29nM.
Cell study
Animal study
Clinical study
Not available

化学结构

208191 - OATD-01 | CAS 2088453-21-6

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