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Nitroxoline

Catalog No.: 16122719
Cas No.: 4008-48-4
Purity : 98% 
16122719 - Nitroxoline | CAS 4008-48-4

Catalog number : 16122719

CAS number : 4008-48-4

分子式 : C9H6N2O3 

分子量 : 190.16 

Iupac 化学名称 : Nitroxoline 

Smile : c1cc2c(ccc(c2nc1)[N+](=O)[O-])O

InChiKey : GBFQOBPPJULZSN-UHFFFAOYSA-N

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同义词8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol|5-Nitro-8-hydroxyquinoline 
英文同义词8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol|5-Nitro-8-hydroxyquinoline 
分子式C9H6N2O3 
分子量190.16 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1cc2c(ccc(c2nc1)[N+](=O)[O-])O
InChiKeyGBFQOBPPJULZSN-UHFFFAOYSA-N
InChiInChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)9-6(8)2-1-5-10-9/h1-5,12H
MDLMFCD06015325
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Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.Nitroxoline significantly reduces extracellular DQ-collagen IV degradation by all evaluated cancer cell lines using spectrofluorimetry. Nitroxoline also markedly decreases tumor cell invasion monitored in real time and reduces the invasive growth of multicellular tumor spheroids, used as a 3D in vitromodel of tumor invasion. Endothelial tube formation is significantly reduced by nitroxoline in an in vitro angiogenesis assay 

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