Netarsudil(Mesylate)
编号: 712181
Cas号: 1422144-42-0
纯度: ≧98%
Netarsudil( AR-11324) is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Netarsudil(Mesylate) |
|---|---|
| Iupac 化学名称 | (S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimethanesulfonate |
| 同义词 | AR-13324; AR13324; AR 13324; Netarsudil Mesylate |
| 英文同义词 | AR-13324; AR13324; AR 13324; Netarsudil Mesylate |
| 分子式 | C30H35N3O9S2 |
| 分子量 | 645.74 |
| Smile | CS(=O)(O)=O.CS(=O)(O)=O.O=C(OCC1=CC=C([C@@H](CN)C(NC2=CC3=C(C=NC=C3)C=C2)=O)C=C1)C4=CC=C(C)C=C4C |
| InChiKey | QQDRLKRHJOAQDC-FBHGDYMESA-N |
| InChi | InChI=1S/C28H27N3O3.2CH4O3S/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;2*1-5(2,3)4/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H3,(H,2,3,4)/t26-;;/m1../s1 |
| Cas号 | 1422144-42-0 |
| 相关CAS号 | 1422144-42-0 (mesylate) 1254032-66-0 (free base) 1253952-02-1 (HCl) |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
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