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Nastorazepide

Catalog No.: 6111110
Cas No.: 209219-38-5
Purity : 98% 
6111110 - Nastorazepide | CAS 209219-38-5

Catalog number : 6111110

CAS number : 209219-38-5

分子式 : C29H36N4O5 

分子量 : 520.62 

Iupac 化学名称 : Nastorazepide 

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同义词Z-360 
英文同义词Z-360 
分子式C29H36N4O5 
分子量520.62 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.


Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent.
Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice.


 

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