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NTP42

Catalog No.: 2051509
Cas No.: 2055599-51-2
Purity : 98% Min.
2051509 - NTP42 | CAS 2055599-51-2

Catalog number : 2051509

CAS number : 2055599-51-2

分子式 : C25H23F2N3O5S

分子量 : 515.5318

Iupac 化学名称 : N-(tert-Butylcarbamoyl)-5-cyano-2-((4'-(difluoromethoxy)-(1,1'-biphenyl)-3-yl)oxy)benzenesulfonamide

Smile : O=S(C1=CC(C#N)=CC=C1OC2=CC(C3=CC=C(OC(F)F)C=C3)=CC=C2)(NC(NC(C)(C)C)=O)=O

InChiKey : RIIKDGPBTPECSW-UHFFFAOYSA-N

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同义词 NTP-42; NTP 42; NTP42;
英文同义词 NTP-42; NTP 42; NTP42;
分子式C25H23F2N3O5S
分子量515.5318
外观固体粉末
纯度98% Min.
可溶性可溶于DMSO
存储干燥、黑暗,短期(日至周)在0-4摄氏度,长期(月至年)在-20摄氏度。
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周。
SmileO=S(C1=CC(C#N)=CC=C1OC2=CC(C3=CC=C(OC(F)F)C=C3)=CC=C2)(NC(NC(C)(C)C)=O)=O
InChiKey RIIKDGPBTPECSW-UHFFFAOYSA-N
InChi InChI=1S/C25H23F2N3O5S/c1-25(2,3)29-24(31)30-36(32,33)22-13-16(15-28)7-12-21(22)34-20-6-4-5-18(14-20)17-8-10-19(11-9-17)35-23(26)27/h4-14,23H,1-3H3,(H2,29,30,31)
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NTP42 is a novel antagonist of the thromboxane prostanoid receptor (TP), currently in development for the treatment of pulmonary arterial hypertension (PAH). PAH is a devastating disease with multiple pathophysiological hallmarks including excessive pulmonary vasoconstriction, vascular remodelling, inflammation, fibrosis, in situ thrombosis and right ventricular hypertrophy.

Mulvaney EP, Reid HM, Bialesova L, Bouchard A, Salvail D, Kinsella BT. NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension. BMC Pulm Med. 2020;20(1):85. Published 2020 Apr 6. doi:10.1186/s12890-020-1113-2

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