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NSC697923

Catalog No.: 16122791
Cas No.: 343351-67-7
Purity : 98% 

NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.NSC697923 selectively inhibits PMA-induced NF-B activation, and also inhibits IB phosphorylation by both RANKL and LPS. NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-B activity in ABC-DLBCL cells. In addition, NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, and also induces apoptosis of primary DLBCL cells. [1] In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation. 

For research use only. We do not sell to patients.

Chemical Information

名称NSC697923
Iupac 化学名称NSC697923 
同义词N/A 
英文同义词N/A 
分子式C11H9NO5S 
分子量267.26 
InChiKey
InChi
Cas号343351-67-7
Related CAS

Ordering Information

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Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122791 - NSC697923 | CAS 343351-67-7

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