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NQDI-1

Catalog No.: 16122772
Cas No.: 175026-96-7
Purity : 98% 
16122772 - NQDI-1 | CAS 175026-96-7

Catalog number : 16122772

CAS number : 175026-96-7

分子式 : C19H13NO4 

分子量 : 319.31 

Iupac 化学名称 : NQDI-1 

Smile : CCOC(=O)c1c-2c3c(cccc3[nH]c1=O)C(=O)c4c2cccc4

InChiKey : UFJGFNHRMPMALC-UHFFFAOYSA-N

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同义词N/A 
英文同义词N/A 
分子式C19H13NO4 
分子量319.31 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCCOC(=O)c1c-2c3c(cccc3[nH]c1=O)C(=O)c4c2cccc4
InChiKeyUFJGFNHRMPMALC-UHFFFAOYSA-N
InChiInChI=1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)
MDLMFCD03265970
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NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.NQDI 1 inhibits the expression of ASK1 and downstream targets in the HI model. It also inhibits injury and apoptosis in the brain cortex. Intracerebroventricularly injection of NQDI 1 after neonatal rats brain HI significantly attenuates acute HI cerebral injury by inhibiting cell apoptosis. The treatment of NQDI-1 markedly inhibits the expression of ASK1 following HI in the perinatal rat, accompanied by a decrease of p-JNK, p-c-Jun, p53 and caspase 3, which were the downstream targets of ASK1 

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