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NLG919(GDC0919)

Catalog No.: 52246
Cas No.: 1402836-58-1
Purity : 98% 
52246 - NLG919(GDC0919) | CAS 1402836-58-1

Catalog number : 52246

CAS number : 1402836-58-1

分子式 : C18H22N2O 

分子量 : 282.38 

Iupac 化学名称 : 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol 

Smile : OC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4

InChiKey : YTRRAUACYORZLX-UHFFFAOYSA-N

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同义词NLG 919;NLG-919;GDC0919;RG6078. 
英文同义词NLG 919;NLG-919;GDC0919;RG6078. 
分子式C18H22N2O 
分子量282.38 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature 
SmileOC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4
InChiKeyYTRRAUACYORZLX-UHFFFAOYSA-N
InChiInChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
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NLG919 is a promising and potent direct enzymatic inhibitor of IDO,In preclinical models, NLG919 showed dose dependent activation and proliferation of effector T cells, producing dramatic regression of large established tumors. Additionally, NLG919 showed enhanced immune activation and tumor regression when combined with Indoximod in this system.

Reference:
1.J Immunother Cancer. 2014; 2(Suppl 3): P250. Published online 2014 Nov 6. doi:  10.1186/2051-1426-2-S3-P250
   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292544/

 

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