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Mubritinib

Catalog No.: 16071022
Cas No.: 366017-09-6
Purity : 98% by HPLC 
16071022 - Mubritinib | CAS 366017-09-6

Catalog number : 16071022

CAS number : 366017-09-6

分子式 : C25H23F3N4O2 

分子量 : 468.47093 

Iupac 化学名称 : (E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole 

Smile : N1(N=NC=C1)CCCCC1=CC=C(OCC=2N=C(OC2)\C=C\C2=CC=C(C=C2)C(F)(F)F)C=C1

InChiKey : ZTFBIUXIQYRUNT-MDWZMJQESA-N

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同义词Mubritinib; TAK 165 
英文同义词Mubritinib; TAK 165 
分子式C25H23F3N4O2 
分子量468.47093 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileN1(N=NC=C1)CCCCC1=CC=C(OCC=2N=C(OC2)\C=C\C2=CC=C(C=C2)C(F)(F)F)C=C1
InChiKeyZTFBIUXIQYRUNT-MDWZMJQESA-N
InChiInChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
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Mubritinib, also known as TAK-165, is a protein kinase inhibitor which was under development by Takeda for the treatment of cancer. It completed phase I clinical trials (may be discontinued since 2008). Mubritinib(TAK 165) is a potent EGFR, HER2 and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 ÂM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5. Mubritinib(TAK 165) displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Mubritinib(TAK 165) exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. 

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