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Motesanib

Catalog No.: 52810
Cas No.: 453562-69-1
Purity : 98% 
52810 - Motesanib | CAS 453562-69-1

Catalog number : 52810

CAS number : 453562-69-1

分子式 : C22H23N5O 

分子量 : 373.45 

化学名称 : Motesanib

Smile : CC1(CNc2c1ccc(c2)NC(=O)c3cccnc3NCc4ccncc4)C.OP(=O)(O)O.OP(=O)(O)O

InChiKey : ONDPWWDPQDCQNJ-UHFFFAOYSA-N

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分子式C22H23N5O 
分子量373.45 
纯度98% 
可溶性DMSO 
SmileCC1(CNc2c1ccc(c2)NC(=O)c3cccnc3NCc4ccncc4)C.OP(=O)(O)O.OP(=O)(O)O
InChiKeyONDPWWDPQDCQNJ-UHFFFAOYSA-N
InChiInChI=1S/C22H23N5O.2H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;2*1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);2*(H3,1,2,3,4)
MDLMFCD12407403
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Motesanib (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. 

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