Mizoribine,Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug. The compound was first observed in Tokyo, Japan, in 1971. It is a natural product, first isolated from the mould Eupenicillium brefeldianum. Mizoribine (MZB) is an imidazole nucleoside that has been used in renal transplantation, and in steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases.
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化学信息
| 名称 | Mizoribine |
| Iupac 化学名称 | Mizoribine |
| 同义词 | Bredinin; HE 69; He69; He-69; NSC289637; NSC-289637; NSC 289637; Bredinin |
| 英文同义词 | Bredinin; HE 69; He69; He-69; NSC289637; NSC-289637; NSC 289637; Bredinin |
| 分子式 | C9H13N3O6 |
| 分子量 | 259.22 |
| Smile | c1nc(c(n1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)N |
| InChiKey | HZQDCMWJEBCWBR-UUOKFMHZSA-N |
| InChi | InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1 |
| Cas号 | 50924-49-7 |
| MDL | MFCD00057221 |
| 相关CAS号 | |
| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |