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Mivebresib

编号: 16123052
Cas号: 1445993-26-9
纯度: 98% 

Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors. 

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化学信息

名称Mivebresib
Iupac 化学名称N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide 
同义词ABBV-075; ABBV 075; ABBV075 
英文同义词ABBV-075; ABBV 075; ABBV075 
分子式C22H19F2N3O4S 
分子量459.4678 
SmileFC1=C(OC2=C(C=C(C=C2)NS(=O)(=O)CC)C=2C3=C(C(N(C2)C)=O)NC=C3)C=CC(=C1)F
InChiKeyRDONXGFGWSSFMY-UHFFFAOYSA-N
InChiInChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
Cas号1445993-26-9
相关CAS号

订购信息

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外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16123052 - Mivebresib | CAS 1445993-26-9

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