Migalastat HCl
编号: 16123048
Cas号: 75172-81-5
纯度: 98%
Migalastat HCl, also known as AT1001 or GR181413A, is a pharmacological chaperone that selectively binds, stabilizes, and increases cellular levels of -Gal A. Oral administration of migalastat HCl reduces tissue GL-3 in Fabry transgenic mice, and in urine and kidneys of some FD patients. Migalastat HCl may provide a potential novel genotype-specific treatment for Fabry Disease (FD). Phase 3 studies are ongoing. Fabry disease (FD) is a genetic disorder resulting from deficiency of the lysosomal enzyme -galactosidase A (-Gal A) which leads to globotriaosylceramide (GL-3) accumulation in multiple tissues.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Migalastat HCl |
|---|---|
| Iupac 化学名称 | Migalastat HCl |
| 同义词 | AT1001; AT 1001; AT-1001; GR181413A; GR 181413A; GR-181413A; 1,5-Dideoxy-1,5-imino-D-galactitol; 1-Deoxygalactonojirimycin; 1-Deoxygalactostatin; Amigal; Migalastat |
| 英文同义词 | AT1001; AT 1001; AT-1001; GR181413A; GR 181413A; GR-181413A; 1,5-Dideoxy-1,5-imino-D-galactitol; 1-Deoxygalactonojirimycin; 1-Deoxygalactostatin; Amigal; Migalastat |
| 分子式 | C6H13NO4 |
| 分子量 | 163.17 |
| Smile | C1[C@@H]([C@H]([C@H]([C@H](N1)CO)O)O)O.Cl |
| InChiKey | ZJIHMALTJRDNQI-OLALXQGDSA-N |
| InChi | InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5+,6-;/m1./s1 |
| Cas号 | 75172-81-5 |
| MDL | MFCD00269962 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
