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MS023

Catalog No.: 6111012
Cas No.: 1831110-54-3
Purity : 98% 

MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM.

MS023 potently inhibits PRMT1 (IC50 = 30 9 nM), PRMT3 (IC50 = 119 14 nM), PRMT4 (IC50 = 83 10 nM), PRMT6 (IC50 = 4 0.5 nM), and PRMT8 (IC50 = 5 0.1 nM). Importantly, MS023 does not inhibit any type II PRMTs (PRMT5 and 9) and type III PRMT (PRMT7) at concentrations up to 10 M. MS023 displays high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. MS023 potently decreases cellular levels of histone arginine asymmetric dimethylation. It also reduces global levels of arginine asymmetric dimethylation and concurrently increased levels of arginine monomethylation and symmetric dimethylation in cells.

 

For research use only. We do not sell to patients.

Chemical Information

名称MS023
Iupac 化学名称MS023 
同义词MS-023; MS 023 
英文同义词MS-023; MS 023 
分子式C17H25N3O 
分子量287.4 
InChiKey
InChi
Cas号1831110-54-3
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

6111012 - MS023 | CAS 1831110-54-3

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